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TRETINOIN
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DeCS
Descriptor
English
:
Tretinoin
Descriptor
Spanish
:
Tretinoina
Descriptor
Portuguese
:
Tretinoína
Synonyms
English
:
Retinoic Acid
Vitamin A Acid
Tree Number:
D02.455.326.271.665.202.495.818.500
D02.455.426.392.368.367.379.249.700.860.500
D02.455.849.131.495.818.800
D23.767.261.700.780
Definition
English
:
An important regulator of
GENE EXPRESSION
during
growth and development
, and in
NEOPLASMS
.
Tretinoin
, also known as retinoic acid and derived from maternal
VITAMIN A
, is essential for normal
GROWTH
; and
EMBRYONIC DEVELOPMENT
. An excess of
tretinoin
can be teratogenic. It is used in the treatment of
PSORIASIS
;
ACNE VULGARIS
; and several other
SKIN DISEASES
. It has also been approved for use in promyelocytic
leukemia
(
LEUKEMIA
, PROMYELOCYTIC, ACUTE).
Pharmacological Action:
Antineoplastic Agents
Keratolytic Agents
See Related
English
:
Receptors, Retinoic Acid
History Note
English
:
80(75); was see under VITAMIN A 1975-79
Allowable Qualifiers
English
:
AD
administration & dosage
AE
adverse effects
AG
agonists
AA
analogs & derivatives
AN
analysis
AI
antagonists & inhibitors
BL
blood
CF
cerebrospinal fluid
CS
chemical synthesis
CH
chemistry
CL
classification
CT
contraindications
DU
diagnostic use
EC
economics
HI
history
IM
immunology
IP
isolation & purification
ME
metabolism
PK
pharmacokinetics
PD
pharmacology
PH
physiology
PO
poisoning
RE
radiation effects
ST
standards
SD
supply & distribution
TU
therapeutic use
TO
toxicity
UR
urine
Record Number:
14606
Unique Identifier:
D014212
Occurrence in VHL
:
Similar:
DeCS
CID-10
SciELO
LILACS
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