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CASPASES
Descriptors Found:
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DeCS
Descriptor
English
:
Caspases
Descriptor
Spanish
:
Caspasas
Descriptor
Portuguese
:
Caspases
Tree Number:
D08.811.277.656.262.500.126
D08.811.277.656.300.200.126
D12.644.360.075.405
D12.776.476.075.405
Definition
English
:
A
family
of intracellular
CYSTEINE ENDOPEPTIDASES
that play a
role
in regulating
INFLAMMATION
and
APOPTOSIS
. They specifically cleave
peptides
at a
CYSTEINE
amino acid that follows an
ASPARTIC ACID
residue.
Caspases
are activated by proteolytic cleavage of a precursor form to yield large and small subunits that form the enzyme. Since the cleavage site within precursors matches the specificity of
caspases
, sequential activation of precursors by activated
caspases
can occur.
Indexing Annotation
English
:
CASPASES
, EFFECTOR and
CASPASES
, INITIATOR and specifics are available
Entry Combination - descr/qualif
English
:
Caspases
/
antagonists & inhibitors
use
Caspase Inhibitors
See Related
English
:
Apoptosis
History Note
English
:
99
Allowable Qualifiers
English
:
AD
administration & dosage
AE
adverse effects
AN
analysis
BI
biosynthesis
BL
blood
CF
cerebrospinal fluid
CS
chemical synthesis
CH
chemistry
CL
classification
CT
contraindications
DF
deficiency
DU
diagnostic use
DE
drug effects
EC
economics
GE
genetics
HI
history
IM
immunology
IP
isolation & purification
ME
metabolism
PK
pharmacokinetics
PD
pharmacology
PH
physiology
PO
poisoning
RE
radiation effects
SE
secretion
ST
standards
SD
supply & distribution
TU
therapeutic use
TO
toxicity
UL
ultrastructure
UR
urine
Record Number:
33826
Unique Identifier:
D020169
Occurrence in VHL
:
Similar:
DeCS
CID-10
SciELO
LILACS
LIS