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2',3'-DIDEOXYNUCLEOSIDES
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DeCS
Descriptor
English
:
Dideoxynucleosides
Descriptor
Spanish
:
Didesoxinucleósidos
Descriptor
Portuguese
:
Didesoxinucleosídeos
Synonyms
English
:
Dideoxyribonucleosides
2',3'-Dideoxynucleosides
Tree Number:
D13.570.230.500
Definition
English
:
Nucleosides
that have two hydroxy groups removed from the
sugar
moiety. The majority of these compounds have broad-spectrum antiretroviral activity due to their action as
antimetabolites
. The
nucleosides
are phosphorylated intracellularly to their 5'-triphosphates and act as chain-terminating inhibitors of viral
reverse transcription.
Indexing Annotation
English
:
antivirals &
antimetabolites
Pharmacological Action:
Antimetabolites
Antiviral Agents
Reverse Transcriptase Inhibitors
History Note
English
:
89
Allowable Qualifiers
English
:
AD
administration & dosage
AE
adverse effects
AG
agonists
AN
analysis
AI
antagonists & inhibitors
BL
blood
CF
cerebrospinal fluid
CS
chemical synthesis
CH
chemistry
CL
classification
CT
contraindications
DU
diagnostic use
EC
economics
HI
history
IM
immunology
IP
isolation & purification
ME
metabolism
PK
pharmacokinetics
PD
pharmacology
PO
poisoning
RE
radiation effects
ST
standards
SD
supply & distribution
TU
therapeutic use
TO
toxicity
UR
urine
Record Number:
23607
Unique Identifier:
D015224
Occurrence in VHL
:
Similar:
DeCS
CID-10
SciELO
LILACS
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