Search on: PRO-OPIOMELANOCORTIN 
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Descriptor English:   Pro-Opiomelanocortin 
Descriptor Spanish:   Proopiomelanocortina 
Descriptor Portuguese:   Pró-Opiomelanocortina 
Synonyms English:   POMC
Pro-Opiocortin  
Tree Number:   D06.472.699.327.935
D06.472.699.631.525.600
D12.644.400.400.935
D12.644.548.365.935
D12.644.548.691.525.690
D12.776.641.650.405.935
D12.776.811.800
Definition English:   A 30-kDa protein synthesized primarily in the ANTERIOR PITUITARY GLAND and the HYPOTHALAMUS. It is also found in the skin and other peripheral tissues. Depending on species and tissues, POMC is cleaved by PROHORMONE CONVERTASES yielding various active peptides including ACTH; BETA-LIPOTROPIN; ENDORPHINS; MELANOCYTE-STIMULATING HORMONES; and others (GAMMA-LPH; CORTICOTROPIN-LIKE INTERMEDIATE LOBE PEPTIDE; N-terminal peptide of POMC or NPP). 
History Note English:   1985 
Allowable Qualifiers English:  
AD administration & dosage AE adverse effects
AG agonists AN analysis
AI antagonists & inhibitors BI biosynthesis
BL blood CF cerebrospinal fluid
CS chemical synthesis CH chemistry
CL classification CT contraindications
DF deficiency DU diagnostic use
DE drug effects EC economics
GE genetics HI history
IM immunology IP isolation & purification
ME metabolism PK pharmacokinetics
PD pharmacology PH physiology
PO poisoning RE radiation effects
SE secretion ST standards
SD supply & distribution TU therapeutic use
TO toxicity UL ultrastructure
UR urine  
Record Number:   21050 
Unique Identifier:   D011333 

Occurrence in VHL: 		 

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