Search on: BETA 2-MICROGLOBULIN 
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Descriptor English:   beta 2-Microglobulin 
Descriptor Spanish:   Microglobulina-2 beta 
Descriptor Portuguese:   Microglobulina-2 beta 
Synonyms English:   Thymotaxin  
Tree Number:   D12.776.124.790.223.100
D12.776.377.715.182.100
Definition English:   An 11-kDa protein associated with the outer membrane of many cells including lymphocytes. It is the small subunit of the MHC class I molecule. Association with beta 2-microglobulin is generally required for the transport of class I heavy chains from the endoplasmic reticulum to the cell surface. Beta 2-microglobulin is present in small amounts in serum, csf, and urine of normal people, and to a much greater degree in the urine and plasma of patients with tubular proteinemia, renal failure, or kidney transplants. 
Indexing Annotation English:   /biosyn /physiol /blood permitted
History Note English:   91(75); was BETA 2 MICROGLOBULIN 1984-90; was see under BETA GLOBULINS 1975-83 
Allowable Qualifiers English:  
AD administration & dosage AE adverse effects
AG agonists AN analysis
AI antagonists & inhibitors BI biosynthesis
BL blood CF cerebrospinal fluid
CS chemical synthesis CH chemistry
CL classification CT contraindications
DF deficiency DU diagnostic use
DE drug effects EC economics
GE genetics HI history
IM immunology IP isolation & purification
ME metabolism PK pharmacokinetics
PD pharmacology PH physiology
PO poisoning RE radiation effects
SE secretion ST standards
SD supply & distribution TU therapeutic use
TO toxicity UL ultrastructure
UR urine  
Record Number:   29233 
Unique Identifier:   D001613 

Occurrence in VHL: 		 

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