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TRIMETREXATE
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DeCS
Descriptor
English
:
Trimetrexate
Descriptor
Spanish
:
Trimetrexato
Descriptor
Portuguese
:
Trimetrexato
Tree Number:
D03.438.786.925
Definition
English
:
A nonclassical
folic acid
inhibitor through its inhibition of the enzyme dihydrofolate reductase. It is being tested for
efficacy
as an antineoplastic agent and as an antiparasitic agent against
PNEUMOCYSTIS
PNEUMONIA
in AIDS
patients
. Myelosuppression is its dose-limiting toxic effect.
Pharmacological Action:
Antifungal Agents
Antimetabolites, Antineoplastic
Folic Acid Antagonists
History Note
English
:
92; was TRIMETREXATE (NM) 1979-91
Allowable Qualifiers
English
:
AD
administration & dosage
AE
adverse effects
AG
agonists
AA
analogs & derivatives
AN
analysis
AI
antagonists & inhibitors
BL
blood
CF
cerebrospinal fluid
CS
chemical synthesis
CH
chemistry
CL
classification
CT
contraindications
DU
diagnostic use
EC
economics
HI
history
IM
immunology
IP
isolation & purification
ME
metabolism
PK
pharmacokinetics
PD
pharmacology
PO
poisoning
RE
radiation effects
ST
standards
SD
supply & distribution
TU
therapeutic use
TO
toxicity
UR
urine
Record Number:
29766
Unique Identifier:
D016597
Occurrence in VHL
:
Similar:
DeCS
CID-10
SciELO
LILACS
LIS