Search on: TALIN 
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Descriptor English:   Talin 
Descriptor Spanish:   Talina 
Descriptor Portuguese:   Talina 
Tree Number:   D12.776.220.985
Definition English:   A 235-kDa cytoplasmic protein that is also found in platelets. It has been localized to regions of cell-substrate adhesion. It binds to INTEGRINS; VINCULIN; and ACTINS and appears to participate in generating a transmembrane connection between the extracellular matrix and the cytoskeleton. 
Indexing Annotation English:   a cytoplasmic protein; /drug eff /ultrastruct permitted
History Note English:   92; was TALIN (NM) 1984-91 
Allowable Qualifiers English:  
AD administration & dosage AE adverse effects
AG agonists AN analysis
AI antagonists & inhibitors BI biosynthesis
BL blood CF cerebrospinal fluid
CS chemical synthesis CH chemistry
CL classification CT contraindications
DF deficiency DU diagnostic use
DE drug effects EC economics
GE genetics HI history
IM immunology IP isolation & purification
ME metabolism PK pharmacokinetics
PD pharmacology PH physiology
PO poisoning RE radiation effects
SE secretion ST standards
SD supply & distribution TU therapeutic use
TO toxicity UL ultrastructure
UR urine  
Record Number:   29792 
Unique Identifier:   D016608 

Occurrence in VHL:
 

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