Search on: SEX HORMONE-BINDING GLOBULIN 
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Descriptor English:   Sex Hormone-Binding Globulin 
Descriptor Spanish:   Globulina de Unión a Hormona Sexual 
Descriptor Portuguese:   Globulina de Ligação a Hormônio Sexual 
Synonyms English:   Testosterone-Estradiol Binding Globulin
Sex Steroid-Binding Protein  
Tree Number:   D12.776.124.790.223.800
D12.776.157.762
D12.776.377.715.182.800
Definition English:   A glycoprotein migrating as a beta-globulin. Its molecular weight, 52,000 or 95,000-115,000, indicates that it exists as a dimer. The protein binds testosterone, dihydrotestosterone, and estradiol in the plasma. Sex hormone-binding protein has the same amino acid sequence as ANDROGEN-BINDING PROTEIN. They differ by their sites of synthesis and post-translational oligosaccharide modifications. 
Indexing Annotation English:   does not refer to all sex hormones: refers to a specific protein in the blood binding only testosterone or estradiol; for other sex hormone-binding globulins consider ANDROGEN-BINDING PROTEIN & PROGESTERONE-BINDING GLOBULIN; DF: SHBG
See Related English:   Androgen-Binding Protein
 
History Note English:   77; SEX STEROID-BINDING PROTEIN was SEX-STEROID-BINDING PROTEIN (NM) 1981-91; ESTRADIOL-BINDING GLOBULIN & TESTOSTERONE-BINDING GLOBULIN were see SEX HORMONE-BINDING GLOBULIN 1977-92 
Allowable Qualifiers English:  
AD administration & dosage AE adverse effects
AG agonists AA analogs & derivatives
AN analysis AI antagonists & inhibitors
BI biosynthesis CF cerebrospinal fluid
CS chemical synthesis CH chemistry
CL classification CT contraindications
DF deficiency DU diagnostic use
DE drug effects EC economics
GE genetics HI history
IM immunology IP isolation & purification
ME metabolism PK pharmacokinetics
PD pharmacology PH physiology
PO poisoning RE radiation effects
SE secretion ST standards
SD supply & distribution TU therapeutic use
TO toxicity UL ultrastructure
UR urine  
Record Number:   22292 
Unique Identifier:   D012738 

Occurrence in VHL: 		 

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