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S6 KINASE
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DeCS
Descriptor
English
:
Ribosomal Protein S6 Kinases
Descriptor
Spanish
:
Proteínas Quinasas S6 Ribosómicas
Descriptor
Portuguese
:
Proteínas Quinases S6 Ribossômicas
Synonyms
English
:
S6 Kinase
Tree Number:
D08.811.913.696.620.682.700.862
D12.644.360.600
D12.776.476.600
Definition
English
:
A
family
of protein serine/threonine kinases which act as intracellular signalling intermediates.
Ribosomal protein S6 kinases
are activated through
phosphorylation
in response to a variety of
HORMONES
and
INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS
.
Phosphorylation
of
RIBOSOMAL PROTEIN S6
by
enzymes
in this class results in increased expression of 5' top MRNAs. Although specific for
RIBOSOMAL PROTEIN S6
members of this class of kinases can act on a number of
substrates
within the cell. The immunosuppressant
SIROLIMUS
inhibits the activation of
ribosomal protein S6 kinases.
See Related
English
:
Coffin-Lowry Syndrome
Ribosomal Protein S6
History Note
English
:
2003(1998); use RIBOSOMAL PROTEIN S6 KINASES (NM) 1985-1997
Allowable Qualifiers
English
:
AD
administration & dosage
AE
adverse effects
AN
analysis
AI
antagonists & inhibitors
BI
biosynthesis
BL
blood
CF
cerebrospinal fluid
CS
chemical synthesis
CH
chemistry
CL
classification
CT
contraindications
DF
deficiency
DU
diagnostic use
DE
drug effects
EC
economics
GE
genetics
HI
history
IM
immunology
IP
isolation & purification
ME
metabolism
PK
pharmacokinetics
PD
pharmacology
PH
physiology
PO
poisoning
RE
radiation effects
SE
secretion
ST
standards
SD
supply & distribution
TU
therapeutic use
TO
toxicity
UL
ultrastructure
UR
urine
Record Number:
33474
Unique Identifier:
D019893
Occurrence in VHL
:
Similar:
DeCS
CID-10
SciELO
LILACS
LIS