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RGS PROTEINS
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DeCS
Descriptor
English
:
RGS Proteins
Descriptor
Spanish
:
Proteínas RGS
Descriptor
Portuguese
:
Proteínas RGS
Synonyms
English
:
Regulators of G-Protein Signaling Proteins
Tree Number:
D12.644.360.325.150.750
D12.776.402.150.750
D12.776.476.325.150.750
Definition
English
:
A large
family
of evolutionarily conserved
proteins
that function as negative regulators of
HETEROTRIMERIC GTP-BINDING PROTEINS
.
RGS PROTEINS
act by increasing the GTPase activity of the G alpha subunit of a heterotrimeric GTP-binding protein, causing it to revert to its inactive (GDP-bound) form.
Indexing Annotation
English
:
do not confuse with
GTP-BINDING PROTEIN REGULATORS
; not the same as RGS tripeptide
Pharmacological Action:
GTP Phosphohydrolase Activators
History Note
English
:
2000; for RGS PROTEIN (G-PROTEIN SIGNALING) use GTPASE-ACTIVATING PROTEINS (NM) 1997-1999
Allowable Qualifiers
English
:
AD
administration & dosage
AE
adverse effects
AG
agonists
AN
analysis
AI
antagonists & inhibitors
BI
biosynthesis
BL
blood
CF
cerebrospinal fluid
CS
chemical synthesis
CH
chemistry
CL
classification
CT
contraindications
DF
deficiency
DU
diagnostic use
DE
drug effects
EC
economics
GE
genetics
HI
history
IM
immunology
IP
isolation & purification
ME
metabolism
PK
pharmacokinetics
PD
pharmacology
PH
physiology
PO
poisoning
RE
radiation effects
SE
secretion
ST
standards
SD
supply & distribution
TU
therapeutic use
TO
toxicity
UL
ultrastructure
UR
urine
Record Number:
34487
Unique Identifier:
D020710
Occurrence in VHL
:
Similar:
DeCS
CID-10
SciELO
LILACS
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