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POST-TRANSCRIPTIONAL GENE SILENCING
Descriptors Found:
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DeCS
Descriptor
English
:
RNA Interference
Descriptor
Spanish
:
Interferencia de ARN
Descriptor
Portuguese
:
Interferência de RNA
Synonyms
English
:
Gene Silencing, Post-Transcriptional
Post-Transcriptional Gene Silencing
Tree Number:
G05.355.315.203.374.790
Definition
English
:
A
gene silencing
phenomenon whereby specific dsRNAs (
RNA
, DOUBLE-STRANDED) trigger the degradation of homologous mRNA (
RNA
, MESSENGER). The specific dsRNAs are processed into SMALL INTERFERING
RNA
(siRNA) which serves as a guide for cleavage of the homologous mRNA in the
RNA-INDUCED SILENCING COMPLEX
.
DNA METHYLATION
may also be triggered during this process.
See Related
English
:
RNA, Small Interfering
RNA-Induced Silencing Complex
History Note
English
:
2003
Allowable Qualifiers
English
:
DE
drug effects
IM
immunology
PH
physiology
RE
radiation effects
Record Number:
37644
Unique Identifier:
D034622
Occurrence in VHL
:
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DeCS
CID-10
SciELO
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