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DeCS
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Descriptor English:
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No-Observed-Adverse-Effect Level
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Descriptor Spanish:
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Nivel sin Efectos Adversos Observados
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Descriptor Portuguese:
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Nível de Efeito Adverso não Observado
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Synonyms English:
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No-Observed-Effect Level
NOAEL
NOEL
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Tree Number:
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E05.940.600
G07.690.620
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Definition English:
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The highest dosage administered that does not produce toxic effects. The NOAEL will depend on how closely dosages are spaced (lowest-observed-adverse-effect level and no-observed-effect level) and the number of animals examined. The ultimate objective is usually to determine not the "safe" dosage in laboratory animals but the "safe" dosage for humans. Therefore, the extrapolation most often required of toxicologists is from high-dosage studies in laboratory animals to low doses in humans. (Casarett and Doull's Toxicology: The Basic Science of Poisons, 4th ed) |
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Indexing Annotation English:
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NIM; coord with specific drug /tox (IM); DF: note short X refs
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History Note English:
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96
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Record Number:
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32662
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Unique Identifier:
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D019055
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Occurrence in VHL:
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Similar:
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DeCS CID-10 SciELO LILACS LIS
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