Search on: INDOLEAMINE-PYRROLE 2,3,-DIOXYGENASE 
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Descriptor English:   Indoleamine-Pyrrole 2,3,-Dioxygenase 
Descriptor Spanish:   Indolamina-Pirrol 2,3,-Dioxigenasa 
Descriptor Portuguese:   Indolamina-Pirrol 2,3,-Dioxigenase 
Tree Number:   D08.811.682.690.416.333
Definition English:   A dioxygenase with specificity for the oxidation of the indoleamine ring of TRYPTOPHAN. It is an extrahepatic enzyme that plays a role in metabolism as the first and rate limiting enzyme in the kynurenine pathway of TRYPTOPHAN catabolism. 
History Note English:   2006(1990) 
Allowable Qualifiers English:  
AD administration & dosage AE adverse effects
AN analysis AI antagonists & inhibitors
BI biosynthesis BL blood
CF cerebrospinal fluid CS chemical synthesis
CH chemistry CL classification
CT contraindications DF deficiency
DU diagnostic use DE drug effects
EC economics GE genetics
HI history IM immunology
IP isolation & purification ME metabolism
PK pharmacokinetics PD pharmacology
PH physiology PO poisoning
RE radiation effects SE secretion
ST standards SD supply & distribution
TU therapeutic use TO toxicity
UL ultrastructure UR urine
Record Number:   50656 
Unique Identifier:   D050503 

Occurrence in VHL:
 

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