Search on:
IMMUNOPHILINS
Descriptors Found:
1
Displaying:
1 .. 1
1 / 1
DeCS
Descriptor
English
:
Immunophilins
Descriptor
Spanish
:
Inmunofilinas
Descriptor
Portuguese
:
Imunofilinas
Tree Number:
D08.811.399.325.500.400
D12.776.543.750.705.400
D12.776.827.275
Definition
English
:
Members of a
family
of highly conserved
proteins
which are all cis-trans peptidyl-prolyl
isomerases
(
PEPTIDYLPROLYL ISOMERASE
). They bind the immunosuppressant drugs
CYCLOSPORINE
;
TACROLIMUS
and
SIROLIMUS
. They possess rotamase activity, which is inhibited by the immunosuppressant drugs that bind to them.
Indexing Annotation
English
:
don't confuse X ref NEUROPHILINS with
NEUROPILINS
History Note
English
:
2004(1999); for NEUROPHILIN use VASCULAR ENDOTHELIAL GROWTH FACTOR (NM) 1997-2003
Allowable Qualifiers
English
:
AD
administration & dosage
AE
adverse effects
AN
analysis
AI
antagonists & inhibitors
BI
biosynthesis
BL
blood
CF
cerebrospinal fluid
CS
chemical synthesis
CH
chemistry
CL
classification
CT
contraindications
DF
deficiency
DU
diagnostic use
DE
drug effects
EC
economics
GE
genetics
HI
history
IM
immunology
IP
isolation & purification
ME
metabolism
PK
pharmacokinetics
PD
pharmacology
PH
physiology
PO
poisoning
RE
radiation effects
SE
secretion
ST
standards
SD
supply & distribution
TU
therapeutic use
TO
toxicity
UL
ultrastructure
UR
urine
Record Number:
33828
Unique Identifier:
D020104
Occurrence in VHL
:
Similar:
DeCS
CID-10
SciELO
LILACS
LIS