Search on: GLYCATION END PRODUCTS, ADVANCED 
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Descriptor English:   Glycosylation End Products, Advanced 
Descriptor Spanish:   Productos Finales de Glicosilación Avanzada 
Descriptor Portuguese:   Produtos Finais de Glicosilação 
Synonyms English:   Glycation End Products, Advanced  
Tree Number:   D12.776.643.500
Definition English:   Products derived from the nonenzymatic reaction of GLUCOSE and PROTEINS in vivo that exhibit a yellow-brown pigmentation and an ability to participate in protein-protein cross-linking. These substances are involved in biological processes relating to protein turnover and it is believed that their excessive accumulation contributes to the chronic complications of DIABETES MELLITUS. 
History Note English:   93 
Allowable Qualifiers English:  
AD administration & dosage AE adverse effects
AG agonists AN analysis
AI antagonists & inhibitors BL blood
CF cerebrospinal fluid CS chemical synthesis
CH chemistry CL classification
CT contraindications DU diagnostic use
DE drug effects EC economics
GE genetics HI history
IM immunology IP isolation & purification
ME metabolism PK pharmacokinetics
PD pharmacology PH physiology
PO poisoning RE radiation effects
SE secretion ST standards
SD supply & distribution TU therapeutic use
TO toxicity UL ultrastructure
UR urine  
Record Number:   30709 
Unique Identifier:   D017127 

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