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FACTOR H
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DeCS
Descriptor
English
:
Complement Factor H
Descriptor
Spanish
:
Factor H de Complemento
Descriptor
Portuguese
:
Fator H do Complemento
Synonyms
English
:
Factor H
Tree Number:
D12.776.124.486.274.920.325.200
D12.776.124.790.223.200
D12.776.377.715.182.200
Definition
English
:
An important soluble regulator of the alternative pathway of
complement activation
(
COMPLEMENT ACTIVATION
PATHWAY, ALTERNATIVE). It is a 139-kDa glycoprotein expressed by the
liver
and secreted into the
blood
. It binds to
COMPLEMENT C3B
and makes iC3b (inactivated complement 3b) susceptible to cleavage by
COMPLEMENT FACTOR I
.
Complement factor H
also inhibits the
association
of C3b with
COMPLEMENT FACTOR B
to form the C3bB proenzyme, and promotes the dissociation of Bb from the C3bBb complex (
COMPLEMENT C3
CONVERTASE, ALTERNATIVE PATHWAY).
Pharmacological Action:
Complement Inactivating Agents
History Note
English
:
93; was COMPLEMENT FACTOR H (NM) 1978-92
Allowable Qualifiers
English
:
AD
administration & dosage
AE
adverse effects
AG
agonists
AN
analysis
AI
antagonists & inhibitors
BI
biosynthesis
CF
cerebrospinal fluid
CS
chemical synthesis
CH
chemistry
CL
classification
CT
contraindications
DF
deficiency
DU
diagnostic use
DE
drug effects
EC
economics
GE
genetics
HI
history
IM
immunology
IP
isolation & purification
ME
metabolism
PK
pharmacokinetics
PD
pharmacology
PH
physiology
PO
poisoning
RE
radiation effects
SE
secretion
ST
standards
SD
supply & distribution
TU
therapeutic use
TO
toxicity
UL
ultrastructure
UR
urine
Record Number:
30775
Unique Identifier:
D017242
Occurrence in VHL
:
Similar:
DeCS
CID-10
SciELO
LILACS
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