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DISINTEGRINS
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DeCS
Descriptor
English
:
Disintegrins
Descriptor
Spanish
:
Desintegrinas
Descriptor
Portuguese
:
Desintegrinas
Tree Number:
D12.644.138
Definition
English
:
A
family
of polypeptides purified from
snake venoms
, which contain the arginine-glycine-aspartic acid (RGD) sequence. The RGD tripeptide binds to integrin receptors and thus competitively inhibits normal integrin-ligand interactions.
Disintegrins
thus block adhesive functions and act as
platelet aggregation inhibitors.
Indexing Annotation
English
:
polypeptides from snake venom;
platelet aggregation
inhib
Pharmacological Action:
Platelet Aggregation Inhibitors
History Note
English
:
97; was DISINTEGRINS (NM) 1992-96
Allowable Qualifiers
English
:
AD
administration & dosage
AE
adverse effects
AG
agonists
AN
analysis
AI
antagonists & inhibitors
BI
biosynthesis
BL
blood
CF
cerebrospinal fluid
CS
chemical synthesis
CH
chemistry
CL
classification
CT
contraindications
DF
deficiency
DU
diagnostic use
DE
drug effects
EC
economics
GE
genetics
HI
history
IM
immunology
IP
isolation & purification
ME
metabolism
PK
pharmacokinetics
PD
pharmacology
PH
physiology
PO
poisoning
RE
radiation effects
SE
secretion
ST
standards
SD
supply & distribution
TU
therapeutic use
TO
toxicity
UR
urine
Record Number:
33035
Unique Identifier:
D019483
Occurrence in VHL
:
Similar:
DeCS
CID-10
SciELO
LILACS
LIS