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CLASS I ANTIGENS
Descriptors Found:
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DeCS
Descriptor
English
:
Histocompatibility Antigens Class I
Descriptor
Spanish
:
Antígenos de Histocompatibilidad Clase I
Descriptor
Portuguese
:
Antígenos de Histocompatibilidade Classe I
Synonyms
English
:
Class I Antigens
Tree Number:
D12.776.395.550.489
D12.776.543.550.421
D23.050.301.500.100
D23.050.705.552.100
Definition
English
:
Membrane glycoproteins
consisting of an alpha subunit and a
BETA 2-MICROGLOBULIN
beta subunit. In
humans
, highly polymorphic
genes
on CHROMOSOME 6 encode the alpha subunits of class I
antigens
and play an important
role
in determining the serological specificity of the surface antigen. Class I
antigens
are found on most nucleated
cells
and are generally detected by their reactivity with alloantisera. These
antigens
are recognized during
GRAFT REJECTION
and restrict cell-mediated lysis of virus-infected
cells.
Indexing Annotation
English
:
human & animal
History Note
English
:
89
Allowable Qualifiers
English
:
AD
administration & dosage
AE
adverse effects
AN
analysis
BI
biosynthesis
BL
blood
CF
cerebrospinal fluid
CH
chemistry
CL
classification
CT
contraindications
DU
diagnostic use
DE
drug effects
EC
economics
GE
genetics
HI
history
IM
immunology
IP
isolation & purification
ME
metabolism
PD
pharmacology
PH
physiology
PO
poisoning
RE
radiation effects
TU
therapeutic use
TO
toxicity
UL
ultrastructure
UR
urine
Record Number:
23664
Unique Identifier:
D015395
Occurrence in VHL
:
Similar:
DeCS
CID-10
SciELO
LILACS
LIS