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APO A-I
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DeCS
Descriptor
English
:
Apolipoprotein A-I
Descriptor
Spanish
:
Apolipoproteína A-I
Descriptor
Portuguese
:
Apolipoproteína A-I
Synonyms
English
:
Apo A-I
Tree Number:
D10.532.091.200.100
D12.776.070.400.200.100
D12.776.521.120.200.100
Definition
English
:
The most abundant protein component of HIGH DENSITY
LIPOPROTEINS
or HDL. This protein serves as an acceptor for
CHOLESTEROL
released from
cells
thus promoting efflux of
cholesterol
to HDL then to the
LIVER
for excretion from the body (reverse
cholesterol
transport). It also acts as a cofactor for LECITHIN
CHOLESTEROL
ACYLTRANSFERASE that
forms
CHOLESTEROL ESTERS
on the HDL
particles
. Mutations of this gene APOA1 cause HDL deficiency, such as in FAMILIAL ALPHA LIPOPROTEIN DEFICIENCY
DISEASE
and in some
patients
with
TANGIER DISEASE.
History Note
English
:
1992 (1974); for PRO-APOLIPOPROTEIN A-I (NM) use APOLIPOPROTEINS A & PROTEIN PRECURSORS 1983-2006; for APOLIPOPROTEIN A-I ISOPROTEINS (NM) use APOLIPOPROTEINS A 1980-2006
Allowable Qualifiers
English
:
AD
administration & dosage
AE
adverse effects
AG
agonists
AN
analysis
AI
antagonists & inhibitors
BI
biosynthesis
BL
blood
CF
cerebrospinal fluid
CS
chemical synthesis
CH
chemistry
CL
classification
CT
contraindications
DF
deficiency
DU
diagnostic use
DE
drug effects
EC
economics
GE
genetics
HI
history
IM
immunology
IP
isolation & purification
ME
metabolism
PK
pharmacokinetics
PD
pharmacology
PH
physiology
PO
poisoning
RE
radiation effects
SE
secretion
ST
standards
SD
supply & distribution
TU
therapeutic use
TO
toxicity
UL
ultrastructure
UR
urine
Record Number:
30252
Unique Identifier:
D016632
Occurrence in VHL
:
Similar:
DeCS
CID-10
SciELO
LILACS
LIS